Obstetric and perinatal outcome in teenage pregnancies
1 Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
2 Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Objective. To compare obstetric and perinatal outcome in teenage and non-teenage pregnancies.
Methods. We performed a retrospective analysis of case records of teenage pregnancies from January 2006 to December 2008. The subjects gave birth in the Department of Obstetrics and Gynaecology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia, a referral tertiary care and teaching hospital with over 5 000 deliveries annually. Pregnancy outcomes in girls aged ≤19 years were compared with those in women aged >19 years. A total of 177 teenage pregnancies were compared with 200 pregnancies in older women.
Results. The prevalence of teenage pregnancies was 1.1%. Almost all subjects were in their first pregnancies. The study showed that teenage mothers had a significant risk of delivering low-birth-weight babies. There were no differences in the risk of anaemia, severe pre-eclampsia, caesarean delivery, postpartum haemorrhage or fetal distress in labour compared with the 200 women in the older age group. Of the pregnant teenagers, 26.9% did not receive any antenatal care at all.
Conclusion. The findings suggest that the long-held beliefs about the risks related to teenage pregnancy are not all justified. Early booking, adequate antenatal care and delivery by trained personnel should improve the obstetric and perinatal outcome in this age group.
S Afr J OG 2013;19(3):77-80. DOI:10.7196/SAJOG.679
Teenage pregnancy has traditionally been considered high-risk pregnancy, especially in developing countries. According to World Health Organization data, about half of the world’s population is under 25 years old, 1.8 billion are aged 10 - 25 years, and 88% live in the developing world.1 In Malaysia, the birth rate for 15 - 19-year-old girls in 2008 was an alarming 12.7/1 000 population.2
Factors that may contribute to this problem are lack of education and information about reproductive and sexual health, lack of access to ways to prevent pregnancy, adolescent sexual behaviour, and even certain customs and traditions. Teenage pregnancy has been reported to be associated with an increased risk of pregnancy-induced hypertension, premature labour and anaemia.3-5 The underdeveloped pelvis in younger adolescents can mean that they have more difficulties in childbirth than adults or mature adolescents, who have fully developed bone structure. Research also indicates that pregnant adolescents are less likely to receive prenatal care than older women, often seeking it only in the third trimester, if at all.6 In this study,6 low birth weight was the only significant difference between the two age groups, and it was related to non-utilisation of prenatal care rather than biological age.
Our objective was to examine the prevalence and obstetric and perinatal outcome of teenage pregnancies at the University of Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia, over the 3-year period January 2006 - December 2008.
Information on teenage pregnancy in Malaysia is scarce. Studies so far have been on a small scale, with teenage pregnancy being researched not as the main topic, but as one aspect of high-risk pregnancy. We used data from the UMMC to systematically explore current aspects of teenage pregnancy, with the intention of informing and improving healthcare services for these young mothers.
This was a retrospective study conducted in the Department of Obstetrics and Gynaecology, UMMC. All the medical records from the hospital delivery database were reviewed and all case records of adolescents (age ≤19 years) who delivered at the UMMC from January 2006 to December 2008 were retrieved, together with 200 case records of adult women (age >19 years) who delivered a single infant over the same time period. These controls were matched with the adolescent cases by computer random number generation.
The following variables were extracted from the medical records: maternal age, gestational age at delivery, mode of delivery, obstetric complications, socio-demographic background, number of antenatal visits during the pregnancy, and perinatal complications including low birth weight and stillbirth. The teenage pregnancies were compared with the non-teenage pregnancies.
Anaemia was defined as a haemoglobin concentration <11 g/dl, and preterm delivery was defined as delivery before 37 weeks’ gestation or amenorrhoea. Numbers of deliveries before 34 weeks of amenorrhoea were also noted. Pre-eclampsia was defined as a blood pressure of at least 140/90 mmHg measured on two occasions 6 hours apart, accompanied by proteinuria of at least 300 mg/24 h, or at least 1+ on dipstick testing. Small-for-gestational-age (SGA) infants were defined as those weighing <2 500 g.
Statistical analysis was undertaken using SPSS version 17. Data were analysed using descriptive statistics and expressed as means ±standard deviations. The chi-square test or Student’s t-test was used for comparing mean values. Results were considered to be statistically significant at p<0.05.
The research proposal was approved by the ethical committee of the UMMC.
Of 15 680 women
who gave birth during the 3-year study period, 177 were
adolescents, giving a teenage pregnancy rate of 1.1%. The mean
age of the adolescents was 17.6 years, and 108 (62.0%) were aged
>18 years at the time of delivery. Only 7 (4.0%) were aged
<15 years, and 62 (35.0%) were between 15 and 18 years old.
Table 1 presents the demographic characteristics
of the subjects and the antenatal care they had received.
There were 2 miscarriages and 1 stillbirth. The latter was estimated to have been at between 26 and 28 weeks of amenorrhoea (the patient was unsure of her dates and there were insufficient antenatal data).
The mean gestational age at delivery for the adolescents was premature (<37 weeks), and the adolescents gave birth significantly earlier than the control group; nearly a quarter (24.3%) had preterm deliveries, compared with less than 10% of adults. However, only 13 adolescents (7.0%) delivered at less than 34 weeks’ gestation. The rate of low birth weight was also much higher (24.1%) in the teenage group than in the adult group (7.0%). Moreover, 4.5% of teenage mothers delivered babies of very low birth weight (<1 500 g).
At the time of delivery, 115 (65.0%) of the adolescents were married and 62 (35.0%) were single. In contrast, only 5 women in the adult group were not married. The majority (62.1%) of the adolescents lived with their husbands, 19.8% with their parents, and smaller numbers with a partner (3.9%), relatives (3.4%) or friends (3.4%), or in a shelter (2.8%).
As would be expected, the majority (85.3%) of the adolescents were nulliparous, compared with less than half of the adult women. However, 24 of them (13.6%) of them were para 1 or had previously had miscarriages, and 2 (1.1%) were para 2.
Over a quarter (26.9%) of the pregnant adolescents who did not miscarry (N=175) had not received any antenatal care before presenting to the UMMC to deliver their babies. More than half (54.3%) had had at least one antenatal visit at the UMMC before delivery, and the remainder had sought care from private clinics. However, 59 (62.1%) of those who came to the UMMC for antenatal care presented in the third trimester shortly before delivery; effectively, they are considered to have had inadequate antenatal care. Only 1 adolescent who received antenatal care at the UMMC (1.1%) did so in the first trimester. In contrast, only 12.5% of adult women had no antenatal care at all.
Interestingly, teenage pregnancies in
this study were not associated with significantly higher rates
of postpartum haemorrhage, pre-eclampsia or fetal distress
compared with adult pregnancies (Table 2). In
addition, the proportion of adolescents diagnosed with anaemia
was considerably lower than that of adults.
Teenage pregnancy in developed countries usually occurs outside marriage, and in many communities and cultures carries a social stigma. In other countries and cultures, particularly in the developing world, teenage pregnancy is often within marriage and does not involve social stigma.7 In this study, the majority of the adolescents were over 18 years of age, followed by age 15 - 18 years, and only 4.0% were <15 years old at delivery. The majority were married, and most lived with their husbands or parents. These girls tended to fall into the group who attended several times for antenatal care.
The prevalence of teenage pregnancy over the 3-year study period was 1.1%. This is lower than global figures.7 It is speculated that actual figures may be much higher, because many such pregnancies go unreported. Full data on pregnancies are only available if the mother attends antenatal care.
Studies on teenage pregnancies have shown conflicting results. Most studies have demonstrated an increased risk of pregnancy-induced hypertension, anaemia and premature labour.2 , 3 , 8 , 9 The present study showed an increased risk of preterm delivery, low birth weight and SGA infants. Further analysis showed that only 7.0% of adolescents gave birth before 34 weeks’ gestation. In contrast, no significant differences were seen in the prevalences of anaemia, postpartum haemorrhage and pregnancy-induced hypertension/pre-eclampsia between the adolescents and the adult group. These findings are similar to those in a recent study by Sagili et al.10 A possible explanation is that the majority of our subjects were married (65.0%) and older teenagers (62.0%).
We found that teenage mothers tend to produce babies of low birth weight. This may have a significant health impact in future years with regard to coronary artery disease, hypertension and type 2 diabetes. The intra-uterine environment and intra-uterine exposures have been found to play an important role in lifelong health and disease, awareness of their importance having emerged nearly 50 years ago when a study by Rose11 described a family pattern of coronary heart disease (CHD), stillbirth and infant mortality. Barker and colleagues12 , 13 subsequently made extensive investigations, found high rates of death due to CHD in areas of England and Wales with high neonatal mortality, and proposed that intra-uterine deprivation was an important factor. However, in our study it was not possible to distinguish the causes of low birth weight in teenage pregnancy with certainty.
Many other studies have documented associations between low birth weight and increased incidences of heart disease, hypertension and type 2 diabetes, as well as relevant markers such as abnormal glucose-insulin metabolism and serum cholesterol concentrations.13-17 It is difficult to determine whether the lower birth weight babies born to the adolescents in this study were growth-restricted or premature, because almost half (80; 45.7%) of the subjects who did not miscarry (N=175) first presented to the UMMC in labour, having either had no antenatal visits at all or antenatal visits elsewhere. Of those who attended the UMMC antenatal clinic (N=95), 59 (62.1%) did so for the first time shortly before delivery, and 12 (12.6%) had only one antenatal visit in the third trimester.
Teenage pregnancies tend to be unplanned, and unplanned pregnancies in young adults are at the root of a number of important public health and social challenges. Women who have an unplanned pregnancy are less likely to obtain prenatal care than women whose pregnancies are planned, and their babies are at an increased risk of low birth weight and premature birth. This is borne out by the present study, in which almost half (45.7%) of the pregnant adolescents presented for the first time for delivery at the UMMC.
We also found that a significantly higher percentage of teenage subjects (26.9%) than older women (12.5%) did not make any antenatal visits at all. The teenage patients also had significantly fewer antenatal visits compared with the older age group. These findings may be related to the psychological stress of an unplanned pregnancy and lack of family support. In this regard, studies have shown that in utero exposure to maternal stress may have long-term negative physiological consequences and can directly influence adult health, even in the absence of low birth weight.18 Furthermore, Buss et al. 18 evaluated brain morphology in young adults and found an association between birth weight and the postnatal environment. Lower birth weight was associated with smaller hippocampal volume (a well-established risk factor for depression and psychopathology) only in individuals exposed to postnatal adversity (poor parental bonding). Swanson and Wadhwa19 have suggested that the fetal environment plays an important role in the development of structure and function of body organs, and may also be relevant to the origins of some child mental health disorders.
Our study showed that the adolescents had a significantly higher rate of normal vaginal delivery and a lower caesarean section rate compared with the adult group. It has been postulated that the young adolescent is at increased risk for cephalopelvic disproportion because the bony pelvis has not yet reached its full size. However, the majority of the teenagers in this study were not young adolescents but late teenagers with full bone maturity, which could explain the lower caesarean section rate in the study group compared with the controls. Recent studies have not supported the assumption that teenage pregnancy is associated with adverse outcome.10 , 20 , 21 However, our adolescent mothers had more preterm deliveries and more SGA infants than the adult group.
pregnancy is an unresolved problem in developing countries,
despite various forms of sexual education and
contraceptive advice. This study showed that the risk of
obstetric complications was no higher in adolescents than in
adult women, but that adolescents tended to have less
antenatal care and to deliver smaller babies. Good family
support, early booking and adequate antenatal care should
improve the obstetric and perinatal outcome in teenage
1. United Nations, Department of Economic and Social Affairs, Population Division. World Population Prospects. http://www.alapop.org/2009/Docs/ProjectionsSeminar/FinalPresentations/Presentation_RioNov2011_Heilig.pdf (accessed 10 December 2012).
2. Omar K, Hasim S, Muhammad NA, Jaffar A, Hashim SM, Siraj HH. Adolescent pregnancy outcomes and risk factors in Malaysia. Int J Gynecol Obstet 2010;111(3):220-223. [http://dx.doi.org/10.1016/j.ijgo.2010.06.023]
3. Goldberg GL, Craig CJ. Obstetric complications in adolescent pregnancies. S Afr Med J 1983;64(22):863-864.
4. Jolly MC, Sebire N, Harris J, Robinson S, Regan L. Obstetric risks of pregnancy in women less than 18 years old. Obstet Gynecol 2000;96(6):962-966. [http://dx.doi.org/10.1016/S0029-7844(00)01075-9]
5. Mahavarkar SH, Madhu CK, Mule VD. A comparative study of teenage pregnancy. J Obstet Gynaecol 2008;28(6):604-607. [http://dx.doi.org/10.1080/01443610802281831]
6. Loto OM, Ezechi OC, Kalu BK, Loto A, Ezechi L, Ogunniyi SO. Poor obstetric performance of teenagers: Is it age- or quality of care-related? J Obstet Gynaecol 2004;24(4):395-398. [http://dx.doi.org/10.1080/01443610410001685529]
7. Population Council. Unexplored Elements of Adolescence in the Developing World. Popul Briefs 2006;12(1)1. http://www.popcouncil.org/pdfs/popbriefs/pbjan06.pdf (accessed 18 April 2007).
8. Kurth F, Belard S, Mombo-Ngoma G, et al. Adolescence as risk factor for adverse pregnancy outcome in Central Africa – a cross sectional study. PLoS One 2010;5(12):e14367. [http://dx.doi.org/10.1371/journal.pone.0014367]
9. Chotigeat U, Sawasdiworn S. Comparison outcomes of sick babies born to teenage mothers with those born to adult mothers. J Med Assoc Thai 2011;94(suppl. 3):S27-S34.
10. Sagili H, Pramya N, Prabhu K, et al. Are teenage pregnancies at high risk? A comparison study in a developing country. Arch Gynecol Obstet 2012;285(3):573-577. [http://dx.doi.org/10.1007/s00404-011-1987-6]
11. Rose G. Familial patterns in ischaemic heart disease. Br J Prev Soc Med 1964;18(2):75-80. [http://dx.doi.org/10.1136/jech.18.2.75]
12. Barker DJ. Fetal origins of coronary heart disease. BMJ 1995;311(6998):171-174. [http://dx.doi.org/10.1136/bmj.311.6998.171]
13. Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986;1(8489):1077-1081. [http://dx.doi.org/10.1016/S0140-6736(86)91340-1]
14. Rich-Edwards JW, Stampfer MJ, Manson JE, et al. Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ 1997;315(7105):396-400. [http://dx.doi.org/10.1136/bmj.315.7105.396]
15. Law CM, Shiell AW. Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature. J Hypertens 1996;14(8):935-941. [http://dx.doi.org/10.1097/00004872-199608000-00002]
16. Hales CN, Barker DJ, Clark PM, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991;303(6809):1019-1022. [http://dx.doi.org/10.1136/bmj.303.6809.1019]
17. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH. Growth in utero and serum cholesterol concentrations in adult life. BMJ 1993;307(6918):1524-1527. [http://dx.doi.org/10.1136/bmj.307.6918.1524]
18. Buss C, Lord C, Wadiwalla M, et al. Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men. J Neurosci 2007;27(10):2592-2595. [http://dx.doi.org/10.1523/JNEUROSCI.3252-06.2007]
19. Swanson JD, Wadhwa PM. Developmental origins of child mental health disorders. J Child Psychol Psychiatry 2008;49(10):1009-1019. [http://dx.doi.org/10.1111/j.1469-7610.2008.02014.x]
20. Smith GC, Pell JP Teenage pregnancy and risk of adverse perinatal outcomes associated with first and second births: Population based retrospective cohort study. BMJ 2001;323(7311):476. [http://dx.doi.org/10.1136/bmj.323.7311.476]
21. Lao TT, Ho LF. Obstetric outcome of teenage pregnancies. Hum Reprod 1998;13(11):3228-3232. [http://dx.doi.org/10.1093/humrep/13.11.3228]
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