Review article

A review of the incidence and survival of childhood and adolescent cancer and the effects of treatment on future fertility and endocrine development

M H Botha, T F Kruger

Abstract


Cancer is not uncommon in children. The reproductive system is an important site for late effects of cancer treatment, and normal pubertal development depends on an undamaged hypothalamic-pituitary-gonadal axis. Fertility compromise can occur due to chemotherapy, radiotherapy to the hypothalamic-pituitary-gonadal axis, or surgery. Cryopreservation techniques of germ cells are improving and may offer hope for fertility preservation.

Authors' affiliations

M H Botha, Unit for Gynaecological Oncology, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, Western Cape

T F Kruger, Unit for Reproductive Biology, Department of Obstetrics and Gynaecology, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, Western Cape

Full Text

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Keywords

Adolescent cancer; fertility preservation; cancer treatment; childhood cancer

Cite this article

South African Journal of Obstetrics and Gynaecology 2012;18(2):48-53.

Article History

Date submitted: 2011-08-31
Date published: 2012-03-29

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